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  • Chemical Biology

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  • Chemical News

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    AYRTON SENNA BRITISH F3 CHAMPION 1983 MODEL I was interested to see this paper, which goes into detail on a chemical phenomenon that many have seen but no one understands very well: triboluminescence. That word meets with a blank stare or instant recognition; there’s not much in between. It means “emission of light when a material is physically broken”, and that encompasses… Dragon 1 35 M48A1 Tank
  • Analytical Chemistry

  • Cancer

  • Drug Assays

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    TAMIYA 1 35 U.S. Main Battle Tank M1A2 SEP Abrams TUSK II Model Kit NEW Japan A common question – well, it should be a common question, anyway – is “How do I make sure that this compound collection is a useful one to screen?” There are alternative forms that come down to the same issues – if you’re putting together a new focused screening set, what should be in it?… Read More
  • Biological News

  • Business and Markets

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    I have not been a fan of Patrick Soon-Shiong and his approach to the biopharma business (and the publicity thereof). There’s a new lawsuit that (should its accusation hold up) will make anyone even less of a fan. Here’s a rundown at Endpoints, and one at Forbes. It’s a mess, so I’ll try to untangle… BMW 325i 1 24 ( Fujimi )
  • Analytical Chemistry

    A Close Look at Fragments

    Here’s a look from the D. E. Shaw research team at fragment binding, and even if you don’t do fragment-based drug discovery, it’s worth a read. That’s because the mechanisms by which fragments bind to proteins are most likely the fundamental ones by which larger molecules bind as well; this is the reductionist look at… Read More
  • Analytical Chemistry

    A Look at Proteins in Living Cells

    We spend a lot of time in this sort of work thinking about protein structures. Traditionally that’s been the province of X-ray crystallography, later joined by solution NMR, and more latterly by cryo-electron microscopy. Each of these has its own set of advantages and disadvantages, but one big split is between the solid phase (X-ray… Dragon 1 35 6419 Pz.Beob.Wg.V Ausf.D Model kit
  • Academia (vs. Industry)

    Startup Culture, Starting

    Dragon Models 1 35 Bergepanther mit aufgesetztem Pz.IV turm als Befehlspanzer Many readers of this blog work in the biopharma industry, naturally, and of those, many are in and around the (few) locations where a great many of the companies in the industry are born. I myself am in the Boston/Cambridge area, famously thick with companies large and small, and then you have the Bay area… Hobbyboss 1 35 83868 IDF APC Puma Tank Model Kit
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